Solid State Characterization of E3210 Polymorphs
スポンサーリンク
概要
- 論文の詳細を見る
Polymorphism is an interesting property of crystalline substances of importance in pharmaceutical development. Studies were conducted to identify the most stable of the five polymorphic (one hydrate and four anhydrous) forms of the active pharmaceutical ingredient (API), E3210. Between the different polymorphs, the transformation mechanisms and thermodynamic stability relationships were complex. Form A and B were further characterized by differential scanning calorimetry (DSC) at various heating rates and powder x-ray diffractometry (PXRD; isothermal and temperature controlled). Analysis by DSC revealed that Form A displays a single and large endothermic melting peak. Form B displays two small peaks, one endothermic peak and the other exothermic; the endothermic peak was an enantiotropically-related reversible transformation from Form B to Form B and the exothermic peak was monotropically-related thermodynamically-irreversible transformation from Form B to Form A. Thus, Forms B and B are enantiotropically-related polymorphs, and both are monotropically related to Form A. Form A is the most stable and Form B is metastable.
著者
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TAKIYAMA HIROSHI
Department of Chemical Engineering, Tokyo University of Agriculture and Technology
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Minamisono Takuma
Physical Chemistry Analytical Research Cmc Japan Eisai Pharmaceutical Science & Technology Tsuku
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Takiyama Hiroshi
Department Of Chemical Engineering Tokyo University Of Agriculture And Technology
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Omae Takao
Physical Chemistry Analytical Research Cmc Japan Eisai Pharmaceutical Science & Technology Tsuku
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SATO Yoshiaki
Biomarkers & Personalized Medicine, Eisai Co., Ltd.
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ISHIHARA Hiroshi
DDS Research, Global Formulation-Japan, Eisai Pharmaceutical Science & Technology, Tsukuba Research Laboratories, Eisai Co., Ltd.
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Hasebe Takashi
Physical Chemistry Analytical Research Cmc Japan Eisai Pharmaceutical Science & Technology Tsukuba Research Laboratories Eisai Co. Ltd.
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Sato Yoshiaki
Biomarkers & Personalized Medicine Eisai Co. Ltd.
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Ishihara Hiroshi
Dds Research Global Formulation-japan Eisai Pharmaceutical Science & Technology Tsukuba Research Laboratories Eisai Co. Ltd.
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Minamisono Takuma
Physical Chemistry, Analytical Research, CMC Japan, Eisai Pharmaceutical Science & Technology, Tsukuba Research Laboratories., Eisai Co., Ltd.
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Hasebe Takashi
Physical Chemistry, Analytical Research, CMC Japan, Eisai Pharmaceutical Science & Technology, Tsukuba Research Laboratories., Eisai Co., Ltd.
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Omae Takao
Physical Chemistry, Analytical Research, CMC Japan, Eisai Pharmaceutical Science & Technology, Tsukuba Research Laboratories., Eisai Co., Ltd.
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