Secolignans, Neolignans and Phenylpropanoids from Daphne feddei and Their Biological Activities
スポンサーリンク
概要
- 論文の詳細を見る
Two new secolignans and one new neolignan, named feddeiphenols A—C (1—3), together with eight known compounds (4—11), were isolated from the leaves and stems of Daphne feddei. Their structures were established on the base of spectroscopic methods, mainly extensive NMR, UV spectroscopy, and MS spectrometry. Compounds 1—11 were tested for their anti-human immunodeficiency virus (HIV)-1 activity and cytotoxicity. The results revealed that compounds 1, 2, 3, 7, and 9 showed therapeutic index (TI) values above 30, respectively, and the other compounds also showed weak anti-HIV-1 activity. Compound 1 showed modest cytotoxic activity. The other compounds also showed weak cytotoxic activity.
著者
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Hu Qiu-Fen
Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities), State Eth
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Mu Huai-Xue
Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities), State Eth
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Huang Hai-Tao
Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science
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Lv Hua-Ying
School of Pharmaceutical Sciences, Peking University
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Li Shu-Li
School of Pharmaceutical Sciences, Peking University
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Tu Pen-Fei
School of Pharmaceutical Sciences, Peking University
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Li Gan-Peng
Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities), State Eth
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Mu Huai-Xue
Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities), State Ethnic Affairs Commission & Ministry of Education, P.R. China
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Hu Qiu-Fen
Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities), State Ethnic Affairs Commission & Ministry of Education, P.R. China
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Li Gan-Peng
Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities), State Ethnic Affairs Commission & Ministry of Education, P.R. China