Evidence for Neuroprotective Effect of Sulbutiamine against Oxygen–Glucose Deprivation in Rat Hippocampal CA1 Pyramidal Neurons

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概要

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• Hippocampus is one of the earliest brain regions that gets affected by ischemia, however, no pharmacological therapy exists yet that can fully counteract the ischemic damage. Here we study the effect of sulbutiamine, a synthetic thiamine analogue that can cross the blood–brain barrier easily, on hippocampal neurons under an in vitro model of ischemia, oxygen–glucose deprivation (OGD). We find that exposure to OGD in the presence of sulbutiamine significantly increases neuronal viability and enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner. Overall, here we report, for the first time, the neuroprotective evidence of sulbutiamine on hippocampal CA1 pyramidal neurons under OGD, which may have beneficial implications as a possible therapeutic agent/substance against ischemic insult.

• 公益社団法人　日本薬学会の論文

著者

• Kwag Jeehyun

  Department of Brain and Cognitive Engineering, Korea University

• Majid Aman

  Advanced Medical and Dental Institute, Universiti Sains Malaysia

• Kang Kui

  Department of Ophthalmology, The Catholic University of Korea

関連論文

• Evidence for Neuroprotective Effect of Sulbutiamine against Oxygen–Glucose Deprivation in Rat Hippocampal CA1 Pyramidal Neurons

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