糖尿病モデル動物db/dbマウスにおけるカルシウム代謝異常に対するアスコクロリン誘導体AS-6の効果
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The effect of the Ascochlorin derivative AS-6, a new hypoglycemic agent, on calcium metabolism was studied in genetically obese diabetic mice, C57Bl/ksj-db/db (db/db). Sixteen male db/db mice and seven lean littermates were used. The db/db mice were allocated to two groups (n=8), one of which was fed a commercial chow (Nihon CLEA, CE-2) as was the lean group. The other db/db group was fed CE-2 chow containing 0.1% AS-6 for 10 days. Serum glucose levels in thed b/db controls showed significant (p<0.01) increases of 3.4 times as compared with the lean controls mice. When AS-6 was given, serum glucose was reduced by 23% as compared with the db/db controls mice. Urinary Ca excretion in db/db controls (30.9 ± 8.2 μg/day) was significantly (p<0.01) higher than in the lean controls (6.8 ± 0.6). AS-6 reduced urinary Ca levels by 61%. Urine Ca levels were correlated to serum glucose (r=0.727) and to urine glucose (r=0.910). Serum Ca levels in db/db controls were significantly (p<0.01) higher than in the lean controls (12.63 ± 0.22 vs. 11.63 ± 0.25 mg/dl). AS-6 significantly (p<0.01) reduced serum Ca levels by 9% as compared with the db/db controls. Serum insulin and calcitonin levels in db/db controls were 15.6 times and 6.6 times, respectively, the levels in the lean controls. AS-6 decreased calcitonin levels by 56% as compared with the db/db controls. There was a correlation between serum calcium and insulin in db/db treated with AS-6 or not (r=0.666). The results showed that db/db mice required much insulin release for blood glucose to decrease, that hyperinsulinemia may contribute to increased serum calcium levels, and that potentiation of insulin action by AS-6 lessens hyperglycemia and hypercalcemia in db/db mice.
- 公益社団法人 日本農芸化学会の論文