Erythroid Crisis Caused by Parvovirus B19 Transmitted Via Red Blood Cell Transfusion
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概要
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A 41-year-old man with hairy cell leukemia developed erythroid crisis after the transfusion of red cell concentrate. He was diagnosed with Parvovirus B19 infection based upon the presence of B19-specific IgM antibody and viral DNA in the sera. The repository sample from the corresponding red cell concentrate was negative for B19 antigen by red cell hemo-agglutination method, but was found to contain B19 virus DNA. Furthermore, a genomic PCR direct sequencing showed that B19 in both patients sera and repository sample were identical. This is the first report directly demonstrating the transmission of B19 through B19 antigen-negative red cell concentrate transfusion. Further accumulation of the cases is warranted to estimate its incidence and to reconsider the screening methods of blood products.
著者
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Mori Takehiko
Division Of Hematology Department Of Medicine Keio University School Of Medicine
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Kizaki Masahiro
Department Of Hematology Saitama Medical Center Saitama Medical University
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Okamoto Shinichiro
Division Of Hematology Department Of Internal Medicane Keio University School Of Medicine
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Yokoyama Kenji
Division Of Hematology Department Of Medicine Keio University School Of Medicine
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TSUKADA Yuiko
Division of Hematology, Department of Medicine, Keio University School of Medicine
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Ishida Akaru
Division of Internal Medicine, Tachikawa Hospital Federation of National Public Service Personnel Mutual Aid Associations, Japan
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Handa Makoto
Transfusion Medicine and Cell Therapy, Keio University School of Medicine, Japan
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Kizaki Masahiro
Department of Hematology, Saitama Medical Center, Saitama Medical University, Japan
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