A case of cutaneous B-cell pseudolymphoma with high frequency of local recurrence

概要

論文の詳細を見る
The potential for certain cutaneous B-cell pseudolymphomas (CBPL) to progress to cutaneous B-cell lymphoma (CBCL) has been reported.We report a case of CBPL. A 44-year-old female presented with a 6-year history of ill-defined redbrown plaque with numerous small nodules on her left cheek. Although the lesion had been treated with surgical extirpation, a number of intralesional steroid injections, topical steroids and oral antibiotics for 6 years at previous hospitals, it had recurred frequently. The biopsy revealed a dense lymphocytic infiltrate admixed with eosinophils and focal reactive lymphoid follicles. Immunophenotypic studies did not show the presence of phenotypic aberrance, coexpression of markers, monotypic immnoglobulin (Ig) light chain and lack of cell surface Ig expression in CD20-positive cells. Furthermore, gene rearrangement of the JH gene was negative via PCR. This case did not fulfill the criteria of CBCL, but the high frequency of local recurrence at short interval should be considered worrisome for potential progression to lymphoma. Local radiation therapy was effective for the treatment of this case. [Skin Cancer (Japan) 2004; 19: 367-371]
日本皮膚悪性腫瘍学会の論文