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We report a case that is strongly suspected as ungual melanoma with spontaneous regression.A 52-year old woman was first seen in February 1997 with a 20-year history of longitudinal melanonychia of the right great toe.In recent two years the brown pigmentation has covered the rest of the nail. Histopathological observation showed melanocytes in the basal cell layer of the nail fold but not of the matrix. The diagnosis of early ungual melanoma was made clinically, so we scheduled for total resection of the nail including the nail matrix and nail bed. But in September 1998, the melanonychia began to disappear at a part of the proximal nail plate. So we decided to follow up her without surgical treatment. The whole body investigation demonstrated no evidence of metastasis. In July 1999, the melanonychia remains at the small part of the distal nail plate and the patient has been kept under periodic observation.
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