Melanoma associated hypopigmentation を生じた3例の悪性黒色腫

概要

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The significance of the association between the appearance of hypopigmentation in patients with melanoma and the prognosis is still not clear. It was postulated that, in melanoma, an immune response is responsible for the destruction of the malignant as well as the normal pigmented cells, and that the eventual development of hypopigmented vitiligo-like patches in melanoma patients improves their prognosis. We report clinical and histological results in three patients with melanoma and widespread hypopigmented vitiligo-like patches. In the hypopigmented patches DOPA-reaction-positive basal melanocytes became far fewer than in the normal surrounding skin. Also, Mel-5-positive basal melanocytes became fewer than in the normal surrounding skin and the residual melanocytes showed long dendrites.
日本皮膚悪性腫瘍学会の論文
1998-10-30