Studies on the intra-hepatic vascular changes in preand early cirrhosis of the choline-deficient rats

スポンサーリンク

概要

• 論文の詳細を見る

• An attempt was made to investigate the correlation between intra-hepatic vascular changes and histogenesis of fatty cirrhosis in the rats fed with a choline-deficient diet prescribed by Hartroft for 1 to 6 months. Intra-hepatic vascular changes were observed by a mean of a prepara tion of the liver infused with colored plastik or gelatin solutions. Progression of fatty liver and cirrhosis was evaluated histologically by the criteria of Hoffbauer et al. Portal pressure was appraised from intra-splenic pressure.Liver cirrhosis was found in over 90% of rats fed with a choline-deficient diet for 6 months. Portal pressure showed a tendency to increase with histological progression of the liver. Distortion of the hepatic and portal veins and anastomoses between each of the terminal branches of the hepatic vein were observed in the liver having slight to moderate fibrosis (stage 3A). In the reconstructed liver by fibrous band without regeneration nodules (stage 3B), features of compression in the small hepatic and portal veins, anastomoses between the hepatic and portal veins or each of the portal veins, and disorganization of the vessels in the area surrounded by fibrous band were observed. When regenerating nodules developed in the scattered area of the liver (stage 4A), the intra-nodular vessels were compressed toward outside of the nodules, showing basket-like appearance, and this feature was prominent near by the terminal hepatic veins. When development of regeneration nodules became marked (stage 4B), conspicuous compression of relatively large vessels in the both veins, especially in the hepatic vein, was observed. Blood supply through the portal vein was preserved in each nodule. And some nodules were supplied portal blood through one terminal branch and the others were done through 2 or more branches.These results would indicate that hepatic fibrosis was preceeded by the changes in the hepatic veins, and intra-hepatic vascular changes became prominent with progress of liver cirrhosis. The differences of blood supply in each nodule may influence on futher progression of liver cirrhosis.

• 財団法人 日本消化器病学会の論文

著者

• 沢江 源四郎

  金沢大学医学部内科学第1講座

関連論文

• タイトル無し
• タイトル無し
• Studies on the intra-hepatic vascular changes in fatty liver of the choline-deficient rats
• Studies on the intra-hepatic vascular changes in preand early cirrhosis of the choline-deficient rats

スポンサーリンク