Studies on the Pancreas in Liver Diseases:II. Exocrine Function of the Pancreas in Liver Cirrhosis and Chronic Hepatitis
スポンサーリンク
概要
- 論文の詳細を見る
In the previous paper, high incidences of pancreatic lesions, especially pancreatic fibrosis, in hepatic cirrhosis were reported. Here an attempt was made to study exocrine function of the pancreas in chronic liver diseases.Fecal excretion of orally administered 131I-labelled triolein was abnormally high in one of 14 cases with cirrhosis of the liver. In none of 12 cases with cirrhosis, fecal excretion of 131I-labelled serum albumin administered by mouth was abnormally increased. These findings suggest that in cirrhosis of the liver digestion and absorption of fat are impaired in some cases, but those of protein are not impaired.Pancreozymin-secretin test was performed in 12 patients with cirrhosis, 6 patients with chronic hepatitis and 11 controls. After secretin stimulation, volume of duodenal contents was abnormally increased in eight of 12 cases with cirrhosis and in three of 6 cases with chronic hepatitis. Icteric indices of duodenal contents of the groups with hepatic diseases were higher than that of the control, 20 to 60 minutes after secretin stimulation. These findings suggest that considerable part of increased duodenal contents was derived from bile and that increased secretion of bile or pancreatic juice might be ascribed to delay in inactivation of secretin in damaged liver. Thirty to seventy minutes after pancreozymin stimulation, increased duodenal fluid did not dilute amylase activity in chronic hepatitis and hepatic cirrhosis. Therefore it seems that inactivation of pancreozymin is also hindered in the group with chronic liver diseases.Maximal bicarbonate concentration of duodenal contents was lowered in two of 12 cirrhotics and in none of parients with chronic hepatitis. In 10-minute period after pancreozymin stimulation, amylase activity was moderately depressed in three of 12 cirrhotics, but it was not decreased in cases with chronic hepatitis. Total amylase output was not lowered in both cirrhosis and chronic hepatitis groups. Therefore it would be concluded that in cirrhosis of the liver, impairment of exocrine pancreatic function is found, but it is not such a degree as to cause hinderance of digestion of carbohydrates.
- 財団法人 日本消化器病学会の論文
著者
関連論文
- Studies on the Pancreas in Liver Diseases:II. Exocrine Function of the Pancreas in Liver Cirrhosis and Chronic Hepatitis
- Studieson the Pancreas in Liver Diseases:I. Histologic Changes of the Pancreas in Liver Cirrhosis