The Experimental Study on the Gastro-duodenal Ulcer:Especially in the stage of the Recurrence or the Aggravation
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概要
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Since the report on the gastroduodenal ulcers of dogs with the administration of"Cinchophen"was described by Churrchill in 1930, several studies have been reported on the experimental methods producing the ulcers.In this study, the gastroduodenal ulcers of dogs were experimentally produced by"Cinchophen"because they were easily produced and almost similar to those of human, macroscopically as well as microscopically.The recurrent process of the experimentally produced ulcers was precisely observed through the"per-peritoneal"gastroscope and compared with the endoscopic findings of human ulcers obtained in the clinical field.1) The gastric ulcers could be made experimentally in almost 90% of the cases with the administration of 1g of"Cinchophen"daily during about 20 days.The ulcers were mostly found in the area with the pyloric gland in the stomach. Speaking how deep layers these ulcers reach, they were ranked as the grade of"Ul II"or"Ul III".Referring to the ulcers found in the marginal region between two areas with the fundic gland and with the pyloric gland or those found in the adjacent part of pyloric ring, most of the ulcers were deeper, being cassified to"Ul III"or"Ul IV".2) Although the similarity of the endoscopic findings of the initial gastric ulcers between dogs and human seemed to depend partly on their stadium to be observed or their existing area, they found at the lesser curvature of the mid portion of stomach of dogs were almost similar to those of human.There were some differences in the surrounding conditions of the ulcers between dogs and human, that is, the abnormalities of the border of ulcers and the rugal convergence were less in dogs. The coagulated blood and the pieces of food were often found on the ulcer floor which was sometimes covered with white coat in dogs.3) The recurrence or the aggravation of the ulcers could be produced experimentally by the re-administration of"Cinchophen"in 88% of the cases.4) The recurrent ulcers were often found at the border section between the area with the fundic gland and the area with the pyloric gland and were observed to be deeply concave. This might be explained with the concept of"locus minoris resistentiae".The incurable ulcers in the clinical field could be also specified by their form, their marginal status and their location in which they were found.5) The relationship between the initial ulcers and the recurrent ulcers was discussed.The recurrent ulcers were developed more frequently from the outer side of the border of the initial ulcers or riding on the margin of them than being coincident with them.6) The comparison of the recurrent ulcers of dogs was made with those of human. The recurrent ulcers of dogs developing at the border of the scar of the initial ulcer could be easily differentiate from the early stage of the cancer of human be their form or their surroundings, while those recurred eccentrically to the scar could rather be confused with the early cancer (III+IIc).It has to be the prudential problem to differentiate the recurrent ulcer from the early stage of the gastric cancer in the clinical field.7) In 6 of 17 dogs, 7 linear ulcers could be made recurrently.It was proved experimentally that the linear ulcers were produced through the repitition of the recurrence or the aggravation.
- 財団法人 日本消化器病学会の論文