An Electron Microscopic Study of the Change of Reticulin Framework in Acute Viral Hepatitis
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概要
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Spotty hepatic cell necrosis is said to be one of the characteristic histological findings of viral hepatitis. It is the purpose of this investigation to elucidate the submicroscopical change of reticulin framework associated with the necrosis. Three cases of acute viral hepatitis were selected for the study. Of the three cases two were icteric cases of serum hepatitis at the 34th and 19th day after the appearance of jaundice, and another one was a non-icteric case of infectious hepatitis. The results of the study were briefly summarized in the following;1) The change of reticulin framework associated with hepatic cell necrosis was observed as early as icteric stage of acute viral hepatitis.2) In accordance with the mode of hepatic cell necrosis, hydropic swelling on the one hand and condensation on the other, a difference was observed in the proliferation of connective tissue fiber associated with the change of reticulin framework.3) In the area where the necrotic cells showed a degenerative change of coagulation, the proliferation of collagen fiber was intense. A substance of high electron density was observed in the Disse, s space, and a microfibrils of 450Åin diameter was laid down in a condensed fashion. The proliferation of fiber rather than the approximation of the pre-existing reticulin fiber was incriminated to the fibrogenesis of such areas. The areas where the necrotic cells showed a degenerative change of hydropic swelling, on the other hand, the rupture of the cell membrane was conspicuous. The scattering of the cell organella was found. The proliferation of connective tissue fiber had not yet begun. A scanty fibrous structure was found inside of the endothelial cell lining.4) The matrix cells related to the hepatic fibroplasia were searched with special reference to the Kupffer cells, endothelial lining cells, macrophages and so on. No close relation was as yet observed between the production of fibrills and such cells.
- 財団法人 日本消化器病学会の論文
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- An Electron Microscopic Study of the Change of Reticulin Framework in Acute Viral Hepatitis