Light- and Electron-Microscopic Studies on the Effect of 1-Phenyl-1-Hydroxy-n-Pentane on the Secretory Function of the Rat Exocrine Pancreas
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It has been reported by Sarles et al. ('65) and Bonfils et al. ('66) that 1-phenyl-1-hydroxy-n-pentane (PHP) known as a cholagogue caused increase in volume of the pancreatic juice output as well as the bile. In this study, the mode of action of PHP on the pancreatic tissue was morphologically examined.Administrations with a single dosage of PHP in which 10mg/kg, 100mg/kg or 1000mg/kg of PHP were catheterized into the stomach caused washing out of secretory product from the lumen and release of zymogen granules from the acinar cell. That is, 30 minutes after PHP administration the great majority of the acinar cells were markedly depleted of zymogen and the lumen appeared empty. One to two hours after PHP administration, the acinar cells recovered zymogen granules to be same as those before stimulation. It can be said that such an effect of PHP on the pancreatic tissue is quite similar to that of pancreozymin described by Ichikawa ('65).Long term administrations of PHP in which animals were given 10mg/kg or 100mg/kg once a day for a month were also carried out, but the pancreatic tissue always showed normal histological features under physiological conditions.
- 財団法人 日本消化器病学会の論文