A Phase Contrast Microscopic Study of Exfoliated Cells of The Stomach

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II Chronological degeneration of the exfoliated gastric cells.Degeneration of the human exfoliated gastric cells was chronologically studied and its difference in each disease was found.(1) The cells from the normal lining epithelium showed the most rapid degeneration, followed by what appeared to be regenerating epithelial cells from ulcer and polyp, and the malignant cells from the marginal areas of advanced cancer showed the longest survival.(2) The cells from the type IIc of early carcinoma presented similar degenerative process to the regenerating epithelium.(3) In the benign cells, degeneration of the nucleus and cytoplasm start at the same time, whereas in the cell from advanced carcinoma nuclear degeneration preceeds.(4) Karyolysis is ordinarily completed prior to destruction of the cytoplasm.(5) The cells from the central portion of advanced cancer show a marked difference in the speed of degeneration in comparison with the cells from the margins. This was probably due to the nutritional difference, which was proved by an experiment.
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