Pathophysiological Investigations of Peptic Ulcer-Secretory Function and Emptying-:Part II: Gastric emptying in patients with peptic ulcer and the effect of foods on gastric pH and gastric function

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The present paper deals with the secretory function and the emptying of the stomach in cases with peptic ulcer, observed using telemetering pH capsules and phenol red test meal method.1. The alkali time was shortened and the emptying was accelerated in cases of duodenal ulcer, and vice versa in cases of gastric ulcer. The difference between the two diseases was statistically significant (p=0.05), although the difference from those of the healthy controls was not significant. After the disappearance of the niche of ulcer, the emptying became delayed in duodenal ulcer, and accelerated in gastric ulcer, compared to those before treatment.2. The effect of the various foods on the secretion and emptying was observed by means of phenol-red test meal method. The delay of the emptying was seen with glucose solutions (10%, 20%-180ml), and the inhibition of both functions was detected with olieve oil (5%, 10%-180ml). The starch and the egg white showed no definite inclination.3. The in vitro neutralizing capacity of the various foods was proved to be dependent on those protein content. The in vivo antacid effect of the foods was also predominantly influenced by those protein content.The significance of the abnormal motility concerning the pathogenesis and the healing of the ulcer was discussed, together with the problem of the intragastric pH in the treatment of the ulcer.
財団法人日本消化器病学会の論文