Studies on the effect upon acute pancreatitis of Trasylol, an inhibitor of trypsin and kallikrein;:especially, on high-dosage Trasylol therapy

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概要

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• In comparative experimental and clinical studies with different doses of TRASYLOL for the treatment of acute pancreatitis the following results have been obtained:1) Use of TRASYLOL from early after the onset of experimental pancreatitis in the dog was, even when the dosage was low, effective as compared with the control. The results of treatment were evidently much better in a group given high dosage than in the group given low dosage TRASYLOL.This effect was definitely better than those obtained from the conventional way only.2) Clinically TRASYLOL in different dosages was given in addition to the conventional therapy. Taking the analgesic effect, the improvement of the abdominal findings, and the decrease of the serum amylase and catalase as a standard of evaluation, it turned out, that the high dosage TRASYLOL group of patients (1-200, 000 KIU per day) showed the most rapid improvement, followed by the low dosage group (1-50, 000 KIU per day).The conventional therapy alone showed less satisfactory results.3) Examination of the correlation between the starting time of TRASYLOL treatment and its efficacy revealed that the drug is most potent when given at an early stage in the course of the development of acute pancreatitis.4) Cases of acute pancreatitis with marked kidney function disturbances had the kidney function disturbances rapidly improved by TRASYLOL.5) Even in high dosage treatment no side effect of the drug was observed.From the above reported experiments it was concluded that in the early stage of acute pancreatitis high dosage TRASYLOL treatment is of a significant therapeutical value. In addition, its beneficial effects are expectable against intoxication symptoms by pancreatitic toxin, such as kidney function disturbances in acute pancreatitis.

著者

• 松山 辰男

  大阪市立池田病院

• 原田 隆元

  大阪市立池田病院

• 築山 義雄

  大阪市立池田病院

• 久保田 義弘

  大阪市立池田病院

• 沢田 良二

  大阪市立池田病院

• 江上 睦子

  大阪市立池田病院

• 前田 三郎

  大阪市立池田病院

関連論文

• Studies on the effect upon acute pancreatitis of Trasylol, an inhibitor of trypsin and kallikrein;:especially, on high-dosage Trasylol therapy

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