Study on the gastric function by means of test meal method
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概要
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Gastric emptying and secretion were studied by means of test meal method on healthy controls and patients with petic ulcer. The following studies were made by giving water-, caffeine-, or peptontest meal containing phenol red to the subjects, and withdrawing gastric contents after 20 minutes period. Volume of secretion and acid output were calculeted following to Hunt's formula (1951).The results were briefly summerized as follows:1) Good correlation was found between the maximal acid response by gastric tube method and the acid output obtained by test meal method, when 6ug/kg of penta gastrin was used as stimulant. 2) The rate of the emptying and the secretion was proved to be paralled with the volume of test meal, so far as 50ml, 200ml and 500ml of water-test meal were used.3) Both gastric emptying and secretion were stimulated significantly by addition of caffeine to water test meal. Moreover, the similar accelerating effect of caffeine upon the gastric function was observed both in previous oral and parenteral administration. Caffeine was proved to affect upon gastric function not only by its local stimulation but also though systemic effect after absorption.4) Pepton-test meal (2.6%) promoted acid secretion more remarkably than caffeine test meal, but no influence was observed on emptying. Acid outupt obtained by 200ml of pepton test meal in 20minutes period corresponded to 80% of that by maximal histalog stimulation.5) Function of the stomach of patients with peptic ulcer was examined using 200ml of pepton test meal in 20minutes period.High acid output and rapid emptying were detected in duodenal ulcer patients, and low acid output but normal emptying were observed in gastric ulcer patients.The ratio of the acid output obtained by test meal method to maximal histalog response was about 90% in patients with duodenal ulcer, and about 80% in patients with gastric ulcer and normal controls. It was suggested that antral release of gastrin might be more active in cases with duodenal ulcer than in cases with gastric ulcer and in healthy controls.6) Effect of some anticholinergic drugs were examined by test meal method. Propantheline bromide and total alkaloid of the scopolia root were proved to depress both gastric emptying and secretion. However, oral administration of hyoscine butylbromide affected little upon them.
- 財団法人 日本消化器病学会の論文