Studies of Lymph Flow in the Liver by Means of Injection of Patent Blue V in Experimental Disturbances in the Hepatic Blood Flow

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概要

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• Silica Gel of 100-200 meshes was injected into the portal vein of dogs and the peripheral end of the portal vein was blocked to bring about disturbances in the portal blood flow. After this, the changes in the hepatic lymph flow and others were observed over a long period of time. In additions, the hepatic vein of other group of dogs was ligated, and the manner of lymph flow of the liver in such ligated dogs was observed. The results may be summarized as follows.1) Observations were carried on the serial sections (20 μ in thickness) prepared with the liver of dogs given injection of Silica Gel powder into the portal vein. As a result 10 to 20 minutes after the Silica Gel injection there were observed the portal veins blocked with Silica Gel and the other without any such blockade. The construction of liver lobules at this stage was normal. In observing the liver of such dogs with lapse of time no liver cirrhosis developed within the period of 19 months, but there were seen shunt between portal veins and fibrosis and septum formation along the direction of the potal vein. However, there could be detected hardly any round cell infiltration in the parenchyma and the mesenchyma of the liver.2) The portal blood pressure began to rise immediately after the Silica Gel injection, which recovered to normal level several months later, but it rose again with lapse of over 12 months.3) On observing the livers of dogs after the injection of 11% Patent Blue V into the liver, in the liver of normal dogs the dye appeared densely on the liver surface, but with the liver of the test dogs 10 to 20 minutes after the Silica Gel injection as well as several months afterwards the dye appeared on the liver surface in the scattered form aside from the dense and coarse forms Further with lapse of over one year after the Silica Gel injection, dye appeared on the liver surface as well as on the surface of gall bladder in the linear form in addition to the manners of the appearance noted above. 4) In the case where the same dye was injected into the liver of those dogs whose hepatic veins had been ligated, the dye was found to have migrated into the lymph ducts of the gall bladder in every case.

• 財団法人 日本消化器病学会の論文

著者

• 名和 伸

  岡山大学医学部第一内科学教室

関連論文

• 肝疾患時における Patent Blue V 注入法による肝リンパ流の研究
• Studies of Lymph Flow in the Liver by Means of Injection of Patent Blue V in Experimental Disturbances in the Hepatic Blood Flow

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