Experimental Study on Extrahepatic Obstructive Jaundice
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概要
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The present investigation was undertaken to clarify the mechanism of obstructive jaundice, caused experimentally by ligation of the bile duct of dogs, from physiological and morphological viewpoints.The experiment was excuted as follows; (1) The relationship of biliary pressure after ligation and serum components (bile pigment, alkaline phosphatase, GOT and GPT) was investigated. These changes by ligation were measured continuously for 120 hours. (2) By intrabiliary infusion of bile pigment, Evans blue and 198Au under a certain added pressure, the pathway of these substances from bile to hepatic venous blood was traced. Concentration and amount of bile pigment and Evans blue in the thoracic duct lymph and the hepatic venous blood were measured. Using autoradiographical method, the intrahepatic course of the isotope was studied. (3) Hepatic cell function on uptake, conjugaiton and excretion in obstructive jaundice was investigated by intravenous administration of 198Au, 131I-RB and 3H-bilirubin, and infusion of BSP. Distribution of the isotopic substances was analysed by counting radioactivity and microautoradiography. During infusion, serum and biliary BSP concentration was measured.The results are summarized as follows; (1) In obstructive jaundice, hepatic cell is able to excute uptake, conjugation and even excretion into bile canaliculi in the early stage after ligation. Later, when excretion was completely hindered, uptake and conjugation were still carried on with comparatively less activity. (2) Transfer of bile pigment, Evans blue and 198Au through hepatic cell from bile to blood stream was observed.These observations indicate that the hepatic cell shows the function of "bi-directional transfer", and reversed transfer of conjugated bilirubin from hepatic cell to blood is important in developing of obstructive jaundice.
- 財団法人 日本消化器病学会の論文
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関連論文
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- Experimental Study on Extrahepatic Obstructive Jaundice