Histochemical Studies on Leucine Aminopeptidase in Gastric Cancer and its Application on Cytodiagnosis of Gastric Cancer:First Part. Histochemical Studies on Leucine Aminopeptidase in Gastric cancer

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Histochemical studies on Leucine Aminopeptidase (LAP) were made on human stomach, surgically resected due to gastric cancer, gastric polyp and gastric ulcer.The results obtained are summarized as follows:1) Gastric cancer cells of intestine metaplasia origin are LAP negative (with exception of 20-30%) and generally exhibit expansive growth. Above-mentioned exceptional cases show decreased LAP activity with the progression of cell atypism.2) Gastric cancer cells of gastric mucosa propria origin are LAP positive (with exception of 14%) and show intense infiltrative growth.3) LAP activity of gastric cancer cell is considered one of the index of malignancy. The function of the activity however, is not connected with proteolysis of surrounding tissues, but with production of intestine mucous, which also prove Alcian blue positive reaction and alkaline phosphatase activity.4) LAP activity in the stroma of gastric cancer is associated with the fibrous formation, and it does not seem to be reactive changes specific to the neoplasia.
財団法人日本消化器病学会の論文