Effects of Magnesium Sulfate and Other Catharties on the Absorption of Vitamin B12 and Certain Nutrients

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概要

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• It is generally thought that diarrhea may have an adverse effect on absorption, or at least it would not accelerate absorption. No definitive studies have been made to prove the point, however. In this study, the effects of MgSO4, Na2SO4, D-sorbitol, castor oil, and several others were assessed on the absorption of 57Co-B12, 131I-human albumin, 131I-triolein and 59FeCl3 in rats. Absorption was measured from recovery of radioactivity in feces and organs, and/or by whole body counting.It was found that absorption of B12 was increased by MgSO4 and sorbitol, whether the dose of B12 was physiological or supraphysiological, and the effect became apparent late after oral administration. The increase was more marked with a large dose of B12. Castor oil inhibited absorption of small doses of B12, but increased absorption of large doses.The effects of MgSO4 on the speed of B12 transit in the digestive tract were studied and it was disclosed that MgSO4 delayed the descent of gastric content into the bowel, had little effect on the speed of intestinal transit, and that the cecal content which had expanded under the influence of the cathartic regurgitated into the ileum. Increase of B12 absorption is caused most likely by the delayed descent of the nutrient from the stomach and its regurgitation into the ileum from the cecum. The same phenomena may occur in man under the influence of cathartics, It seems that bulk cathartics have little effect on the absorptive capacity of the small intestinal mucosa.

• 財団法人 日本消化器病学会の論文

著者

• 後藤 淳郎

  久留米大学医学部奥田内科

• 後藤 淳郎

  久留米大学医学部第2内科

関連論文

• 福岡県朝倉郡杷木町における流行性肝炎の疫学調査 第1報
• Effects of Magnesium Sulfate and Other Catharties on the Absorption of Vitamin B12 and Certain Nutrients

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