胃癌における消化管への蛋白漏出量の検討
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Quantitative study of serum protein loss into the alimentary tract from the tumor of gastric cancer using 111Indium-transferrin (<SUP>111</SUP>In-Tf) was performed. Gamma counting of <SUP>111</SUP>In-Tf excreted in feces and <SUP>111</SUP>In-Tf scintigram were performed in 24 patients with gastric cancer and 10 controls. Transferrin was labelled by incubating 111MBq (3mCi) of <SUP>111</SUP>In chloride with approximately 13ml of patient plasma <I>in vitro</I>. After intravenous injection of <SUP>111</SUP>In-Tf, an aliquot was weighed and its radioactivity was measured in a gamma-counter. Feces were collected every 24hrs up to 72hrs. Then <SUP>111</SUP>In in the feces was calculated as a percentage of the injection dose.<BR> <SUP>111</SUP>In excreted in the feces within 72hrs in patients with gastric cancer was 3.711±3.87% (mean±SD), which was significantly higher than the 0.48±0.26% in 10 controls. <SUP>111</SUP>In in feces correlated the area of the tumor in the stomach (<I>p</I><0.001). In 18 patients positive scan was recognized and was localized the protein loss in the cavity of the stomach within 10 minutes. Positive scan was found to move along the intestine successively.<BR> <SUP>111</SUP>In-Tf can be useful in assessing of hypoproteinemia of gastric cancer.
- 財団法人 日本消化器病学会の論文
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