残胃癌の特性とその発生機序について
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概要
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To clarify characteristics and development of stump cancers of the stomach, we studied 10 cases (12 lesions) of them with mucin-histochemical and immunohistochemical techniques and gene analysis using polymerase chain reaction. Sixty-seven % of the cancers were mostly composed of gastric-type cells and 67% also showed abnormal accumulation of <I>p</I>53 protein in their nuclei. There were scattered cells with abnormal accumulation of <I>p</I>53 protein in cystically dilatated glands that were often found to be surrounding cancers. Immunohistochemistry of proliferating cell nuclear antigen also demonstrated proliferating activity of these cystic glands. It is suggested that the cystically dilatated gland is precancerous lesion of stump cancers of the stomach. The gene analysis showed less occurrence of K-<I>ras</I> abnormality, and the mutation of <I>APC</I> gene is suggested to be infrequent.
- 財団法人 日本消化器病学会の論文