Down-reguration of liver regeneration by LAK cells. A study for effect of neuraminidase treated LAK cells on liver regeneration.:A study for effect of neuraminidase treated LAK cells on liver regeneration

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Both effect of LAK cells and neuraminidase treated LAK (N-LAK) cells on liver regeneration were investigated after 70% partial hepatectomy in mice.Intravenous transfusion of LAK cells suppressed the liver regeneration depending on cell numbers injected.N-LAK cells accumulated into regenerating liver 1.7 times in cell number compared with LAK cells.Injection of 5×107 LAK cells and N-LAK cells into hepatectomized mice suppressed the liver regeneration by 16.5% and 53.8% respectively.These results indicated that suppression of the liver regeneration by LAK cells was dependent upon the number of injected LAK cells and the degree of accumuration of LAK cells into the liver, namely, LAK cells down-regurate the regeneration of liver cells in the micromilieu.
財団法人日本消化器病学会の論文