Plasma endotoxin measured by the combination of new perchloric acid pretreatment method and endotoxin specific assay in liver cirrhosis.

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Using with the newly modified perchloric acid pretreatment method and endotoxin specific assay (Endospecy), the plasma endotoxin in the patients with liver cirrhosis was investigated. The mean value of plasma endotoxin in control (n=20) was below 9.8pg/ml. The plasma endotoxin level in liver cirrhosis was 5.7±5.3pg/ml (n=70, mean±SD), and 20% of the patients (15 cases) showed above 9.8 pg/ml. Endotoxin level significantly correlated with the severity of liver function based on the Child-Turcotte classification (p<0.01). Plasma endotoxin positively correlated with total bililubin (r=0.417) and ICG clearance test (r=0.298) and negatively correlated with prothrombin time (%) (r=0.497) and HDL-cholesterol (r=0.578) in the patients with liver cirrhosis. There was no correlation between esophageal varices and plasma endotoxin level. Plasma endotoxin was slightly detected in the patients with decompensated cirrhosis, and these data suggest that plasma endotoxin level in cirrhosis is not so elavated.
財団法人日本消化器病学会の論文