Nucleation time and growth time in cholesterol gallstone patients - Factors affecting nucleation time and growth time and effect of UDCA and CDCA.:Factors affecting nucleation time and growth time and effect of UDCA and CDCA

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Nucleation time (NT) and growth time (GT) were measured in gallbladder bile of patients with cholesterol gallstones. NT was significantly shortened (NT<10 days) in pure cholesterol stones but was moderately shortened (11_??_NT_??_21) in mixed and combination stones. GT also was accelerated (GT<7 days) in cholesterol stones. NT was shortened in increased biliary total protein, but on the contrary, was shortened in decreased apo A-I. NT of bile by UDCA therapy but not CDCA was extended. This suggests that increased apo A-I during UDCA therapy might imply extension of NT. The strong negative correlation between GT and CSI of bile suggests that CSI plays an important role in crystal growth.