In vitro cytokine production in patients with HBe antigen positive chronic active hepatitis receiving interferon-.BETA..
スポンサーリンク
概要
- 論文の詳細を見る
Twenty patients with HBe antigen positive, chronic active hepatitis receiving interferon-β (HuIFN-β) for 4 weeks were studied. Within the follow-up period (12.3±2.0 months; mean±SD), nine patients were seroconverted to anti-HBe positive and/or HBe antigen negative.In vitro synthesis of interleukin-1 (IL-1), interleukin-2 (IL-2) and interferon-γ (IFN-γ) were determined from supernatants of peripheral blood mononuclear cells (PBMCs) cultured in the presence of lipopolysaccharide or concanavalin-A. PBMCs from patients before IFN-β treatment secreted markedly reduced levels of IL-1 (p<0.01) and IFN-γ (p<0.01) as compared with healthy controls. However, IFN-γ synthesis in the patients was significantly increased (p<0.05) along with the IFN-β treatment. IL-2 synthesis was similar in chronic active hepatitis B patients before and during IFN-β treatment when compared to normal controls, but after the therapy, the elevation of IL-2 synthesis was observed in accordance with the elevation of serum AST in two cases.Nine patients who seroconverted to anti-HBe positive and/or HBe antigen negative showed the significantly lower levels of DNA polymerase berofe IFN-β treatment than non-responder group. There were no other differences in sex, age, serum AST, histologic activities and cytokine production in vitro between two groups.These results indicate the presense of immunologic deficiencies in patients with HBe antigen positive chronic active hepatitis and give the rationales for the use of interferon treatment on immunologic basis.
- 財団法人 日本消化器病学会の論文
著者
関連論文
- ルポイド型慢性活動性肝炎の合併を認めた家族性Sjögren症候群の一家系
- B型劇症肝炎の回復期に非A・非B型急性肝炎を併発した一症例
- In vitro cytokine production in patients with HBe antigen positive chronic active hepatitis receiving interferon-.BETA..