Endoscopic study on the effect of dietary fiber against 1,2-dimethylhydrazine-induced colonic carcinogenesis in rats.

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The effect of dietary fiber on colonic carcinogenesis was studied endoscopically in rats administered 1, 2-dimethylhydrazine. Colonic tumors appeared about six weeks later in ras fed 15% cellulose diet or 40% wheat bran diet than in those fed basal diet. Furthermore, the incidence of colonic tumor was significantly lower from 23th week to 26th week in the cellulose diet group(p<0.01)and at 26th week in the wheat ban diet group(p<0.05)than in the basal diet group. Although, the incidence of colonic tumor and the mean number of the tumors per rat at sacrifice (30th week) were not significant different between these two high-fiber diet groups and the basal diet group. These two diets significantly increased feces 3 to 4 times in weight and 5 times in volume than basal diet.However, 15% pectin diet could neither inhibit colonic carcinogenesis and nor increase the fecal weight. These results suggested that cellulose and some dietary fibers of wheat bran were effective to retard colonic carcinogenesis, and that the increased fecal weight and volume by fibers may be involved in the inhibitory effect.