Changes of serum HBV-DNA in various types of HBV infection and their clinical significance.

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Serum HBV-DNA was examined in 33 patients with acute hepatitis B (AVH), 15 asymptomatic HBV carriers (ASC), 40 chronic hepatitis B (CH), and the results were analyzed in relation to other HBV markers and clinical features.Serum HBV-DNA was positive in 9 (27.3%) of 33 patients with AVH, who needed longer duration for normalization of GPT as compared with cases negative for HBV-DNA. In ASC, appearance of serum HBV-DNA well correlated with the HBeAg/anti-HBe status. Serum HBV-DNA was detected in all cases of 30 patients with CH positive for HBeAg and in 6 of 10 patients with CH positive for anti-HBe. Serum HBV-DNA was the best parameter to reflect the exacerbation of chronic hepatitis B. Although serum HBV-DNA did not correlate with HBsAg in the liver, good correlation was found between serum HBV-DNA and HBsAg in the liver.These results suggested that serum HBV-DNA was useful as a parameter of prolongation of acute hepatitis B and, at the same time, it could serve as the most sensitive parameter reflecting exacerbation of hepatitis associated with HBV replication in patients with CH.
財団法人日本消化器病学会の論文