Clinical application of pancreatic cancer associated antigen (Span-1 antigen).

概要

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Span-1 antibody is a murine monoclonal antibody which was produced against a human pancreatic cancer cell line SW 1990. A sensitive sandwich radioimmunoassay was developed using this antibody to evaluate its applicability to the diagnosis of various gastrointestinal disorders including pancreatic cancer. Above 400 units/ml of Span-1 antigen was considered to be positive.Serum Span-1 antigen levels in healthy subjects (n=82) were within 400 units/ml. Positive rating in diseases were pancreatic cancer: 90% (n=79), hepatobiliary cancer: 59% (n=44), gastric cancer: 14% (n=182), colon cancer: 13% (n=50), benign G.I.: 5% (n=86), chronic pancreatitis: 8% (n=25), and acute pancreatitis: 10 (n=10).Levels of serum Span-1 antigen correlated well with treatment and recurrence of disease in a patient with pancreatic cancer.Based on these results Span-1 antigen apparently has good predictive value for pancreatic cancer compared with other gastrointestinal cancers and pancreatitis.
財団法人日本消化器病学会の論文