Immunohistochemical investigation of fatty acid binding protein in ileal mucosa of Crohn's disease.

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Fatty acid binding protein (FABP) were studied immunohistochemically in 12 patients with Crohn's disease, 11 patients with intestinal tuberculosis, and 28 control cases in order to clarify the disturbance of absorption and metabolism of fat in Crohn's disease. The patients of Crohn's disease consisted of 6 with intravenous hyperalimentation (IVH) and 6 without IVH. Terminal ileum of surgically resected specimens provided the material for this study. In nonulcerated mucosa, the number of FABP positive cells and the incidence of FABP positive cells in villi showed no significant difference between control cases, intestinal tuberculosis, and Crohn's disease without IVH. But they showed lowering in Crohn's disease with IVH. At the ulcer margin, they revealed no difference between intestinal tuberculosis and Crohn's disease with or without IVH.These results imply the evidence that fatty acid binding protein in ileal absorptive cells exist enough to participate in cellular fatty acid transport and metabolism in Crohn's disease without IVH. Moreover, the decrease of incidence of FABP positive cells in Crohn's disease with IVH might be caused by cessation of fat intake in gut.
財団法人日本消化器病学会の論文