Clinical and experimental studies on cyclic GMP metabolism in acute liver damage.

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In order to examine the mechanism of increased cyclic GMP levels in noncancerous liver diseases such as liver cirrhosis (decompensated) and acute hepatitis (the initial stage), in situ perfusion experiments were tried in rat livers treated with D-galactosamine (Gal-N) intraperitoneally, as a model of acute hepatitis in the rat.Perfusate cyclic GMP levels at 24, 48, and 72 hours afrter Gal-N injection increased significantly compared with that of control. Carbachol-induced cyclic GMP production increased at 24, 48, 72 hours, especially at 72 hours after the treatment. The response caused by carbachol was absolutely inhibited by atropine. Increased 3H-thymidine uptake in the liver was also found at the same time, indicating a close-relationship between the cyclic GMP production and the liver regeneration. Insulin affected additively on cyclic GMP production in regenerated livers.These results indicate that cyclic GMP may play an important role in hepatic regeneration through the muscarinic receptor in the liver.
財団法人日本消化器病学会の論文