虚血性腸炎と抗生剤関連性腸炎における血清免疫グロブリン値と腸管の局所免疫

概要

論文の詳細を見る
Various classes of immunoglobulin (Ig) in sera from 26 patients with ischemic colitis (IC) and 40 patients with antibiotic associated colitis (AAC) were measured and various classes of Ig containing cells and secretory component (SC) were investigated using immunofluorescence technique.The mean value of serum IgE level was significantly increased in irregular ulcer type (IU type) than that of longitudinal ulcer or erosion type (LUE type), AAC, and normal control. The number of IgE containing cells in the biopsy specimens of IU type was much higher than that of LUE type. AAC, and normal control.These findings suggest that the immediate hypersensitivity might play one of the important part of pathogenesis in IU type.In the patients with AAC, the percentage proportions of IgA containing cells and stainability of SC in the inflammed mucosa and normally appeared mucosa were significantly decreased. These results reveal the disturbance of the local defense mechanism concerning with IgA secretory-immunoglobulin system over the total colon. Then it is suggested that in the patient with AAC the entire colonic mucosa might have a possibility to be fallen into inflammation.
財団法人日本消化器病学会の論文