Gastric mucosal changes induced in rat by insertion of the stainless steel spring into the pyloric sphincter.

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Gastric mucosal changes were pathologically studied in rats after surgical insertion of the stainlesssteel spring into the pyloric sphincter. The gastric contents obtained 5 weeks after the spring insertion showed decreased acidity by pH measurement, indicating the regurgitation of the duodenal content. After the spring insertion, the pyloric canal was strongly distended and the pyloric mucosa was thickened at both the sites oral to as well as of direct contact with the spring. Such pyloric mucosa demonstrated histologically hyperplasia of both the foveolar and glandular epithelial cells, mild goblet cell metaplasia, diffuse inflammatory cell infiltration and lymph follicle formations. The fundic mucosa displayed both slight elongation and widening of the gastric pits. Furthermore, in the fundic region after 5 weeks, there occasionally observed a few, focal elevated lesions, which consisted of the foveolar lining cell hyperplasia.These gastric mucosal changes observed after the spring insertion into the rat pyloric canal seem to be similar in several respects to those of chronic gastritis in human.
財団法人日本消化器病学会の論文