Etiologic consideration on the hepatotoxity after dietary chenodeoxycholic acid administration in the rabbits.

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An etiologic mechanism of hepatotoxity after dietary chenodexcycholic acid (CDA) administration in the rabbits was studied. Administration of CDA in the rabbits resulted in a remarkable increase of lithocholic acid (LA) in bile, however, increase of LA in bile was less prominent in the prohibited coprophagy rabbits and substantially nil in the cecectomy with appendectomized rabbits.Seventies in the histological changes manifested as proliferation of bile duct, necrosis of hepatocytes, inflammatory cell infiltration of portal triad, fibrosis and septum formation of the liver were well correlated with quantities of LA in bile.These findings imply that 7α-dehydroxylation of primary bile acid by colonic microflora in the huge cecum and appendix is the primary etiologic factor for increased biliary LA followed by severe hepatic damage in the rabbits fed with CDA.Furthermore, coprophagy promotes recycle of fecal LA and this may play an another important role in increasing biliary LA in the rabbits fed with CDA.
財団法人日本消化器病学会の論文