Changes of serum protein in patients and mice with cancer.

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概要

• 論文の詳細を見る

• The effects of surgical operation or schizophyllan (SPG) on serum proteins in patients with cancer and mice with experimentally transplanted cancer were examined using polyacrylamide gel electrophoresis and two dimensional electrophoresis.Protein components in the mice, designated as LA, LB and LC were detected and were found to have increased in mice with cancer, reccurrence of cancer or treated with SPG.In patients with cancer, acute-phase crude proteins increased but a newly isolated protein component having a molecular weight of approximately 150, 000 decreased.Although it is said that this component can be seen in healthy persons, this study showed that it remained unchanged in patients without cancer and who had had tumors surgically removed, but increased after the administration of SPG.It is suggested that this component could be a factor potentiating the host defence system and might be a useful indicator to differentiate between benign and malignant tumors. In addition, the fact that increased serum protein components in mice after the administration of SPG similar to those in men after the administration of SPG throws an interesting light on the mechanism of anti-cancer activity.

• 財団法人 日本消化器病学会の論文

著者

• 伊藤 久

  杏林大学医学部外科学i教室

• 伊藤 久

  杏林大学医学部第1外科学教室

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