Electron microscopic observation of cysteamine-induced duodenal ulcer in the rat.

スポンサーリンク

概要

• 論文の詳細を見る

• Duodenal mucosal changes induced in rats by subcutaneous injection of cysteamine were observed by stereo, light, and electron microscopy in order to clarify the mechanism of ulcer formation. Initial lesions revealed by electron microscopy were nonspecific degenerations of absorptive epithelial cells of the duodenum 2 hours after administration of 200mg/kg body weight of cysteamine. Microvilli and mitochondria of the injured cells were destroyed. Nuclei lost parachromatin and the cytoplasm became electron-lucent. Such degenerated absorptive epithelial cells were most prominent at the tips of villous folds and exfoliated in progress of cell injury. Thereafter, villous cores were denuded, and erosion and ulcer developed. Endothelial cells of small vessels in lamina propria were scarcely injured. Duodenal mucosal damage was not always accompanied with decrease of mucin in Brunner glands. Therefore, initial lesions of duodenal ulcer seemed to be caused by direct cytotoxic action of cysteamine on epithelial cells.

• 財団法人 日本消化器病学会の論文

著者

• 上坂 好一

  岡山大学医学部第1内科

関連論文

• 食道 Mucosal Bridge を伴つた全身性エリテマトーデスの1症例
• 化学療法することなく14年間生存中の悪性リンパ腫の1例 : 消化管病変を中心に
• Electron microscopic observation of cysteamine-induced duodenal ulcer in the rat.

スポンサーリンク