慢性硬化性乳頭炎に関する実験的研究
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The experimental model of chronic sclerosing papillitis was manufactured in order to elucidate pathogenesis of the disease with special reference to occurrence of irreversible change in the papilla of Vater.The experimental animals, nine weeks old male rabitts, were subjected to laparotomy under i.v. anesthesia. A polychlorethylene catheter was inserted into the papilla of Vater via the pin-hole on duodenum up to the hepatic duct and induwelled for one, tow and four weeks. The induwelling terms consisted with experimental group A, B and C, respectively. Each group was divided into three subgroups according to duration from catheter removal to examination; immediate (A1; n=4, B1; n=3, C1; n=4), one month (A2; n=3, B2; n=2, C2; n=4), and three months (A3; n=3, B3; n=5, C3; n=7), respectively.The external diameter of common bile duct, intraluminal hydrostatic pressure and flow resistance of the papilla of Vater were measured. Cholangiography, serum biochemical examination and histopathological examination of the choledochus and the papilla of Vater were performed.The results were as follows; the experimental model clarified that chronic sclerosing papillitis was produced by chronic intraluminal stimulation with the indwelling catheter for three months. Fibrotic changes of Oddi's muscle was progressive and the muscle was completely fragmented three months after removal of stimulation.
- 財団法人 日本消化器病学会の論文
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