Establishment of mouse monoclonal antibodies against N-terminal peptide of type III procollagen and their use for a histochemical study in the human liver.

スポンサーリンク

概要

• 論文の詳細を見る

• Anti Col 2 region of N-terminal propeptide and anti α1 (III) of type III collagen monoclonal antibodies were established using type III collagen fraction prepared from fetal calf skin as an antigen sourse. These monoclonals had cross reactivities to the respective antigens of fetal and adult human origin, anti Col 2 monoclonal immune stained by an enzyme immunoassay the connective tissues of skin, lung, spleen and liver. The connective tissues of fetal tissue showed stronger staining than those of adult. Pericellular staining along sinusoidal lining with weaker staining of interlobular connective tissue was the typical feature in the normal liver. While it was observed in tissues of hepatocellular carcinoma that carcinoma lesion was stained poorly but the capsel of connective tissue and surrounding tissue without carcinoma was positively stained.

• 財団法人 日本消化器病学会の論文

著者

• 近藤 英明

  岡山大学医学部第1内科

関連論文

• Establishment of mouse monoclonal antibodies against N-terminal peptide of type III procollagen and their use for a histochemical study in the human liver.

スポンサーリンク