A study of the differentiation of generative cells in the gastric mucosa and modification by the environmental change, with reference to vagal denervation.

概要

論文の詳細を見る
The labeling indices of generative cell zone in the gastric mucosa and antral gastrin cells were determined in the vagotomized and non-treated control hamsters by the use of 3H-thymidine autoradiography. The labeling indices of generative cell zone and antral gastrin cells in the vagotomized hamsters showed a transient striking increase immediately after vagotomy, and then they were gradually restored with time. After 10 weeks onward, the labeling indices of generative cell zone leveled off at a slightly high value in the pyloric mucosa and a slightly low value in the fundic mucosa when compared with those in the controls. The labeling indices of antral gastrin cells showed a synchronized change with those of generative cell zone in the pyloric mucosa.Then, the renewal of antral gastrin cells were investigated in both the hamsters 10 weeks after vagotomy and non-treated controls. It was found that the cell cycle time of generative cells in the pyloric mucosa was shortened, and the time required for the differentiation to gastrin cells were also shortened, comparing with those in the controls, in the vagotomized hamsters. Furthermore, it was also suggested that, in the vagotomized hamsters after 10 weeks, the cell cycle time of generative cells in the fundic mucosa was prolonged and this could reduce the cell production of the superficial epithelial cells and glandular cells such as parietal cells in the fundic mucosa.