Tissue and cellular localization of carcinoembryonic antigen (CEA) in gastric cancer and correlation to serum CEA levels and prognosis.

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The localization of CEA in gastric cancer was detected at the light and electron microscopic levels. And correlation between tissue CEA and serum CEA levels or prognosis was analysed. One hundred and thirty resected specimens of gastric cancer were used for light microscopy (LM), the tissue was fixed in formalin and embedded in paraffin. Ten fresh specimens of gastric cancer were used for electron microscopy (EM), the tissue was fixed in PLP solution and frozen. CEA stain was performed using enzyme labeled antibody method. Positive rate of tissue CEA was 74.6%; sig, muc 100%>pap83.3%>tub 76.5%>por 65.1% on histological classification. CEA was positive on the cellular membrane and the cytoplasm by LM, and on the basolateral plasma membrane, the endoplasmic reticulum, the perinuclear space and the Golgi complex by EM in cancer tissue. Positive rate of serum CEA levels was 17.9%, and serum level was higher in positive group of tissue CEA than in negative group, showing higher levels with advancing stage. The prognosis was worse in positive group of tissue CEA than in negative group.
財団法人日本消化器病学会の論文