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Intravenous bolus injection of pGRP in anesthetized dogs at a dose of 60pmol/kg through the cephalic vein caused significant rise in the concentration of serum immunoreactive gastrin. Simultaneous elevation of both gut-glucagon like immunoreactivity and immunoreactive insulin. On the other hand, the release of immunoreactive secretin, VIP and pancreatic glucagon was not stimulated under the same condition.Removal of the N-terminal thirteen, seventeen of eighteen amino acid residues did not affect the response of serum immunoreactive gastrin to pGRP during the infusion. However, the prolonged effect of pGRP was almost completely abolished by this peptide chain shortening. Removal of the nineteen amino acid residues from the N-terinus caused significant decrease of gastrin releasing activity and the removal of next 20th amino acid residue caused disappearance of this activity. Since the pGRP (20-27) was concluded to be the vital active core of pGRP molecule for gastrin releasing activity.pGRP (1-13) itself was inactive upon the gastrin releasing activity, but it seemed to be important for the full biological activity of pGRP.
財団法人日本消化器病学会の論文