:Study about the early stage of chronic pancreatitis and the pattern of the progress of it

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The fibrosis of the pancreas tissue was successfully made by the contact freezing method, and we used it as an experimental chronic pancreatitis model. By using this model, we studied the correlation between the histologic findings and the pancreatogram, especially about the adjacent fibrosis and stricture of the main pancreatic duct.The results were as follows.1) The histologic section and the pancreatogeam showed the stricture of the main pancreatic duct when the periductal fibrosis was advanced.2) On the histologic section, the shape of the main pancreatic duct was sometimes transformed by the parenchymal atrophy, edema and fibrosis. The wall of the pancreatic duct was sometimes stretched by the adjacent fibrosis. I supposed that the pancreatogram reflected these histologic changes as the irregularity and the hardening of the pancreatic duct.3) In some cases, the dilatation of the distal pancreatic duct and secondary histologic changes around it due to the stricture of the proxymal pancreatic duct, were shown.These results revealed that the stricture of the main pancreatic duct due to adjacent fibrosis, was the manifestation of the early stage of chronic pancreatitis. I had the opinion that these results manifestated the pattern of the progress of chronic pancreatitis.
財団法人日本消化器病学会の論文