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The purpose of this study is to find a novel diagnostic marker of hepatocellular carcinoma (HCC).The hepatic tissue zinc content, the serum zinc concentration and the urinary zinc excretion in patients with HCC, with metastatic cancer of the liver and with chronic liver diseases were investigated by atomic absorption spectroscopy. Histochemical and analytical electron microscopical analyses were also made.The hepatic tissue zinc contents in noncancerous portion of the liver in chronic hepatitis with HCC (412.4±155.1μg/gm. d.w.) was significantly (p<0.005) higher than those in chronic hepatitis without HCC (160.9±36.7μg/gm. d.w.). The hepatic tissue zinc contents in noncancerous portion of the liver in liver cirrhosis with HCC (255.8±145.9μg/gm. d.w.) was also significantly (p<0.05) higher than those in liver cirrhosis without HCC (157.0±49.2μg/gm. d.w.).The hepatic tissue zinc contents in various noncancerous portion of the liver with HCC were homogenously increased.Histochemically, stainable zinc were usually found in periportal area of noncancerous portion of the liver.According to this study, the measurement of the hepatic tissue zinc may be of value in the diagnosis of the presence of HCC in the hepatic tissue with chronic hepatitis or with liver cirrhosis, also in four of six cases, the presence of low AFP producing HCC.
財団法人日本消化器病学会の論文