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Although it has been widely accepted that the nuclear DNA content increases in human malignancies, there is a lack of evidence for sequential change of the nuclear DNA content. The present study was undertaken to investigate the nuclear DNA content in relation to the histopathological appearance by means of Feulgen-DNA-cytofluorometry in the rat of MNNG-system. The results indicate that the nuclear DNA content shows bimodal change, i.e., early increase which appeared in the phase of no detectable histological abnormality from at 2 weeks after MNNG-ingestion and late increase just before the recognition of malignancy histopathologically.
- 財団法人 日本消化器病学会の論文