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The method for microassay of tissue plasminogen activator in gastric mucosa specimen obtained by endoscopy was studied by modifying the Astrup's method, and established a new useful and highly reproducible micromethod, applying 0.02% fibrin-agar plate for the preparative extract of tissue plasminogen activator that the activity had a linear relationship in semilogarithmic plotting with the diameter of lysis windows.Using this method, the change in plasminogen activator activity in the gastric mucosa was investigated in patients with gastric ulcer.The mucosal specimens were obtained at the margin of ulcer and at the distal area from ulcer by endoscopy, and control specimens were taken from mucosa of normal stomach.The plasminogen activator activity in the gastric mucosa of patients with active gastric ulcer showed a significant increase regardless of distance from ulcer. Further detailed observations, however, revealed that the increased activity was decreased significantly after medical treatment.On the other hand, the activity in the gastric mucosa of patients with ulcerated gastric cancer showed normal.These results suggest that the increase of tissue fibrinolytic activity in the gastric mucosa is involved in the formation of active gastric ulcer.
- 財団法人 日本消化器病学会の論文