:(2nd Report)

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We have investigated the effect of Cysteamine on gastric acid and pepsin activities with and without vagotomy and organ distribution of 35S-Cysteamine detected with liquid scintillation counter and autoradiography in rats. Truncal vagotomy was performed prior to 24 hours and 7 days before injection of cysteamine. Gastric acid and pepsin activities were investigated for 5 hours after injection. 0.2, μCi/g 35S-Cysteamine was intravenously injected and the distribution of each organs, such as blood, brain, liver, stomach and duodenum was detected. The severity of mucosal injuries was higher in the rats studied at 12 and 24 hours compared to the 3 hours group (p<0.01). The rats treated with truncal vagotomy could not be prevented from ulcer formation. The gastric acid secretion and pepsin activities were increased after injection of Cysteamine. The activities of 35S-Cysteamine in duodenum was highest at 1 hour after injection and high level activity was maintained for 24 hours. 35S-Cysteamine labelled cells were located at mucosal layer accompanied with dilatation of lymph vessels and infiltration of inflammatory cells in 30 min, and 1 hour after injection.In the previous report, we suggested that ulcer formation was resulted in the decreased of mucosal blood flow. In addition, we would like to emphasize correlation between the change of duodenal microcirculation and ulcer formation on the basis of 35S-Cysteamine accumulation of the duodenum. It is suggested that impairment of duodenal microcirculation may be due to release of vasoactive amine from tissue following administration of Cysteamine and contribute to the ulcer formation in rats.
財団法人日本消化器病学会の論文

:(2nd Report)

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