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The relationship between alcoholic fatty liver and lipid peroxide was investigated in rats fed an alcohol liquid diet for six weeks. The following results were observed. First, prolonged ethanol feeding increased concentrations of both hepatic tissue triglyceride (T. G.) and hepatic microsomal lipid peroxide. Second, intraperitoneal administration of α-tocopherol (α-toco.) inhibited hepatic microsomal lipid peroxide induced by ethanol. Third, intraperitoneal administration of clofibrate (CPIB) produced a marked increase in hepatic tissue catalase activity associated with an increase of hepatocytic peroxisomes and also inhibited the induction of both hepatic tissue T.G. and hepatic microsomal lipid peroxide at the time of ethanol feeding. These results suggest that the increase in lipid peroxide may be a causal factor in the development of alcoholic fatty liver.
- 財団法人 日本消化器病学会の論文