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The effects of parenteral nutrients with glucose, amino acids and fat on gastric secretion and the inhibitory mechanism to the gastric secretion of these nutrients in 4 healty subjects and 7 mongrel dogs with Heidenhain pouch were studied.The results showed that, in healthy subjects, tetragastrin-induced gastric acid secretion was significantly reduced by intravenous 20% glucouse and 12% amino acids. And in mongrel dogs, tetragastrin-induced acid secretion of Heidenhain Pouch was similarly reduced by intravenous 50% glucose, while less effect by intravenous 12% amino acids was noted, however no reduced was observed with 10% fat.According our experiments, it might be suggested that the inhibitory effects of intravenous glucose infusion on gastric acid secretion was possibly through the sympathetic nerve.
財団法人日本消化器病学会の論文