:Tissue Derangement of 112 Corticosteroid Treated Autopsy Specimens

概要

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Autopsy specimens of the pancreas from the 112 subjects with corticosteroid treatment and the 109 subjects with no-treatment were examined histologically in order to elucidate the effect of steroid on the exocrine pancreatic tissue.The consequences are that moderate pancreatitis could be observed in 25 cases (53%) out of 47 steroid-treated cases, except for liver cirrhosis and collagen disease, while it was seen in 8 cases (14%) out of 57 non-treated cases.In the corticosteroid treated patients with liver cirrhosis, remarkable pathological changes including pancreatic duct epithelial proliferation, intra-pancreatic ductal inflammatory cell infiltration, inflammatory cell infiltration into interstitium of pancreatic lobules and parenchymal focal necrosis were observed more significantly than in non-treated cirrhotic pancreas.Consequently, corticosteroid seemed to induce focal necrosis of pancreatic parenchyma associated with inflammatory cell infiltration, fibrosis and hemorrhage.
財団法人日本消化器病学会の論文